Physical, biological, and social landscapes define a dynamic living surface. This surface manifests tremendous variation across our planet's biosphere and shapes the terrain in which pathogens interact with hosts. These interactions are modulated by a complex of ecology, geography, social structure, human-animal-environmental interactions, and pathogen-host molecular biology. This complex is the core of our conceptualization of landscape epidemiology. At the Lab we investigate zoonotic pathogens combining methods from spatial and infectious disease epidemiology with methods from population ecology, community ecology, landscape ecology, and biogeography to employ transdisciplinary One Health approaches to zoonosis inference, prediction, surveillance, and prevention. Understanding the natural nidus of infection is our primary focus, and the One Health paradigm our driving and unifying philosophy.