Physical, biological, and social landscapes define a dynamic living surface. This surface manifests tremendous variation across our planet's biosphere and shapes the terrain in which pathogens interact with hosts. These interactions are modulated by a complex of ecology, geography, social structure, human-animal-environmental interactions, and pathogen-host molecular biology. This complex is the core of our conceptualization of applied epidemiology. At the Lab we investigate disease etiologies using methods from traditional spatial epidemiology, as well as more modern applications of biogeography, community ecology, and geocomputation to inform infectious disease inference and prediction. Delineating the natural nidus of zoonotic disease is a primary focus of much our work, and the One Health paradigm our driving and unifying philosophy.